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Test Code NPPC Peripheral Nerve Pathology Consultation

Additional Codes


Powerchart: Sural Nerve Biospy

Epic: LAB3560 Sural Nerve Biopsy

Useful For

Evaluating diseases of the nerve and disorders that affect nerve function


This consultation is for fixed tissue, slides, or blocks.

Testing Algorithm

When this test is ordered, 1 or more of the listed reflex tests will be performed and charged separately. The reviewing neuromuscular pathologist will determine the need for additional testing.


Wet tissue for consultation: When adequate tissue is provided, routine testing will include: teased fiber examination, Congo red stain, Turnbull blue stain, methyl violet stain, Masson’s trichrome stain, leukocyte common antigen, luxol fast blue/PAS stain, KP-1 macrophage, methylene blue stain, and hematoxylin and eosin stain.


Slides and blocks sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing at an additional charge at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. In addition, testing requested by the referring physician (immunostains, molecular studies, etc) may not be performed if deemed unnecessary by the reviewing Mayo Clinic neuromuscular pathologist. For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.

Reporting Name

Peripheral Nerve Path Consult

Specimen Type


Specimen Required

Specimen Type: Nerve biopsy tissue, slides, or block

Collection Instructions: Prepare and transport specimen per instructions in Nerve Biopsy Specimen Preparation Instruction (T580) in Special Instructions. A Nerve Biopsy Kit (T457: fees apply) containing fixatives and buffer is available at an additional fee. For ordering information, call 507-284-8065.

Additional Information:

1. Tentative clinical diagnosis

2. Name of nerve biopsied

3. Date of biopsy

4. Indication for nerve biopsy

5. Biopsies from same site will be processed as 1 specimen.

6. Biopsies from different sites require separate orders and separate specimen vials.


1. 3 segments (vials) of left sural nerve are processed as 1 specimen, 1 order number.

2. 1 left sural nerve and 1 left superficial peroneal nerve requires 2 separate orders.

Specimen Stability Information

Specimen Type Temperature Time
Tissue Varies

Reject Due To

Note: No specimen should be rejected. If questions, contact laboratory.

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

88305-Surgical pathology, gross and microscopic examination (if appropriate)

88313 x 6-Congo red, Luxol fast blue-periodic acid schiff, Masson's trichrome, methylene blue, methyl violet, and Turnbull blue stains (if appropriate)

88321-Consultation and report on referred slides prepared elsewhere (if appropriate)

88323-Consultation and report on referred material requiring preparation of slides (if appropriate)

88323-26-Consultation and report on referred unstained slides (if appropriate)

88325-Consultation, comprehensive, with review of records and specimens, with report on referred material (if appropriate)

88362-Teased fibers, preparation and analysis


PNS1 IHC Initial Single Antibody Stain

88342 (if appropriate)


PNS2 IHC, Each Add’l Antibody stain

88341 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NPPC Peripheral Nerve Path Consult 59465-5


Result ID Test Result Name Result LOINC Value
NPPC Peripheral Nerve Path Consult 59465-5

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
NPWT NervePath, Level IV, Wet Ts No, (Bill Only) No
NPOS NervePath Consult, Outside Slide No, (Bill Only) No
NPSP NervePath Consult, w/Slide Prep No, (Bill Only) No
NPUP NervePath Consult, w/USS Prof No, (Bill Only) No
NPCHX NervePath Consult, w/Comp Rvw of Hx No, (Bill Only) No
NWTF Neuro Path Exam Tiss w Teased Fiber No, (Bill Only) No
CRED Congo Red, Nrv ST No, (Bill Only) No
TBLU Turnbull Blue, Nrv ST No, (Bill Only) No
METHV Methyl Violet, Nrv ST No, (Bill Only) No
MASN Masson's Trichrome, Nrv ST No, (Bill Only) No
LUXO Luxol Fast Blue/PAS, Nrv ST No, (Bill Only) No
MTHB Methylene Blue, Nrv ST No, (Bill Only) No
PNS1 IHC Initial Single Antibody Stain No, (Bill Only) No
PNS2 IHC, Each Add'l Antibody Stain No, (Bill Only) No

Method Name

Nerve Biopsy Surgical Pathology Consultation and Review of Outside Material


1. Pathology/Cytology Information (T707) in Special Instructions

2. Nerve Biopsy Patient Information (T458) in Special Instructions