Sign in →

Test Code SHBG Sex Hormone-Binding Globulin (SHBG), Serum

Additional Codes

MLAB: YLV

Powerchart: Sex Hormone Binding Globulin

Epic: LAB2710 Sex Hormone Binding Globulin

MA Cerner: Sex Hormone-Binding Globulin (SHBG).

Reporting Name

Sex Hormone Binding Globulin, S

Useful For

Diagnosis and follow-up of women with symptoms or signs of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism)

 

An adjunct in monitoring sex-steroid and anti-androgen therapy

 

An adjunct in the diagnosis of disorders of puberty

 

An adjunct in the diagnosis and follow-up of anorexia nervosa

 

An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)

 

A possible adjunct in diagnosis and follow-up of insulin resistance and cardiovascular and type 2 diabetes risk assessment, particularly in women

 

In laboratories without access to bioavailable testosterone or equilibrium dialysis-based "true" free testosterone assays, sex hormone-binding globulin measurement is crucial in cases when assessment of the free testosterone fraction (aka free androgen index or calculated free testosterone) is required. At Mayo Medical Laboratories, both bioavailable testosterone (TTBS / Testosterone, Total and Bioavailable, Serum) and free testosterone (TGRP / Testosterone, Total and Free, Serum) measurements are available. Free testosterone (TGRP) is measured by equilibrium dialysis, obviating the need for sex hormone-binding globulin measurements to calculate free androgen fractions.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  60 days

Reference Values

CHILDREN

Males

Tanner Stages*

Mean Age

Reference Range (nmol/L)

Stage I

7.1

31-167

Stage II

11.5

49-179

Stage III

13.6

5.8-182

Stage IV

15.1

14-98

Stage V

18.0

10-57

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years. For boys, there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.

 

Females

Tanner Stages*

Mean Age

Reference Range (nmol/L)

Stage I

7.1

43-197

Stage II

10.5

7.7-119

Stage III

11.6

31-191

Stage IV

12.3

31-166

Stage V

14.5

18-144

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.

 

ADULTS          

Males: 10-57 nmol/L

Females (non-pregnant): 18-144 nmol/L

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-12 a.m., Saturday; 6 a.m.-6 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84270

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SHBG Sex Hormone Binding Globulin, S 13967-5

 

Result ID Test Result Name Result LOINC Value
SHBG Sex Hormone Binding Globulin, S 13967-5

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross OK

Icterus

NA

Other

NA

Method Name

Automated Chemiluminescent Immunometric Assay